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Home > Gastroenterology > Gastrointestinal Stromal Tumor
Location - stomach 60 to 70%, small intestine 20 to 30%. 10% - colon, rectum, esophagus. Extraintestinal sites possible. Symptoms - palpable abdominal mass, pain, early satiety, anorexia, vomiting, GI bleed. Incidence - 1 to 3% of all malignant GI tumors. Pathogenesis - possibly originating from precursor cells to the Interstial Cells of Cajal. Markers - CD 117 antigen as marker for KIT receptor kinase, 95%. Diagnosis - endoscopy, endoscopic ultrasound, CT with oral and IV contrast, 18F-FDG PET scan Treatment - surgical resection, imatinib mesylate - Gleevec - inhibits tyrosine kinase activity of KIT Please consider an official gastroenterology consult and refer to the sources below. Discussion - on Google+. Custom Gastroenterology Search Engine
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