Home > Gastroenterology > Gastrointestinal Stromal Tumor
Location - stomach 60 to 70%, small intestine 20 to 30%. 10% - colon, rectum, esophagus. Extraintestinal sites possible.
Symptoms - palpable abdominal mass, pain, early satiety, anorexia, vomiting, GI bleed.
Incidence - 1 to 3% of all malignant GI tumors.
Pathogenesis - possibly originating from precursor cells to the Interstial Cells of Cajal.
Markers - CD 117 antigen as marker for KIT receptor kinase, 95%.
Diagnosis - endoscopy, endoscopic ultrasound, CT with oral and IV contrast, 18F-FDG PET scan
Treatment - surgical resection, imatinib mesylate - Gleevec - inhibits tyrosine kinase activity of KIT
Please consider an official gastroenterology consult and refer to the sources below.
Discussion - on Google+.